Human Physiology of Genetic Defects Causing Beta-cell Dysfunction

Beta Cell Dysfunction and Insulin Resistance

Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states induce hyperglycemia and therefore increase insulin demand. Beta cell dysfunction results from inadequate glucose sensing to stimulate insulin secretion therefore elevated glucose concentrations prevail. Persiste...

Red cell membrane and erythropoiesis genetic defects.

In recent years, the frontline of red cell membrane research has shifted. Seeking new mutations in known genes has been taken over by the quest of new genes. It remains that many natural mutations, both in human and mice, have an irreplaceable heuristic value. For example, it is some of these mutations that eventually paved the way to the demonstration that the band 3 and the Rh complexes form ...

Malaria and red cell genetic defects.

The study of inherited RBC resistance to malaria has increased our knowledge of the biochemistry and physiology of the host-parasite interaction and suggested potential sites for therapeutic intervention. Discovery by Jensen and Trager of the in vitro culture system for P falciparum has facilitated research in this area. Known RBC defects may affect invasion, growth, or merozoite liberation (Fi...

Physiology and Dysfunction

Copulation normally culminates with two physiologically distinct events known as emission and ejlzctllafion.3~ 3o Emission is the release of sperm and accessory gland fluids into the pelvic urethra. Ejacdafion is the forceful expulsion of the combined fluids (i.e., semen) from the urethra. The associated perceptual-cognitive event called ovgrrsm in humans has not been characterized in nonhuman ...

Brucella Infection Causing Abortion in Human Beings